Peptidoglycan Cross-Linking in Glycopeptide-Resistant Actinomycetales
نویسندگان
چکیده
منابع مشابه
Kinetics of cross-linking of peptidoglycan in Bacillus megaterium.
The extent and rate of cross-linking of diaminopimelic acid in the peptidoglycan of Bacillus megaterium have been determined by a new procedure. The method is based on the reaction of nitrous acid with the unprotected amino groups of non-cross-linked diaminopimelic acid. Pulse label experiments in a mutant where diaminopimelic acid is incorporated specifically into peptidoglycan demonstrated th...
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Cross linking of high density polyethylene (HDPE) was first performed via high energy10 Mev electron beam (EB) irradiation. HDPE was also cross linked withDicumyle peroxide (DCP).The gel content of samples was determined by solvent extraction.Degree of cross linking was evaluated by hot set apparatus; as well .In order to clarify the effectof nature of cross linking, correlation of electrical p...
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The biosynthesis of pentaglycine, the cross-linking peptide in the cell wall peptidoglycan of Sfaphylococcus aureus, requires glycyl-tRNA as a donor of glycine. The pentaglycine is introduced by sequential addition of glycine from glycyltRNA to the e-amino group of the L-lysine residue of the pentapeptide in the lipid-linked precursor. The direction of elongation of the pentaglycine chain is fr...
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The cell wall of Staphylococcus aureus is characterized by an extremely high degree of cross-linking within its peptidoglycan (PGN). Penicillin-binding protein 4 (PBP4) is required for the synthesis of this highly cross-linked peptidoglycan. We found that wall teichoic acids, glycopolymers attached to the peptidoglycan and important for virulence in Gram-positive bacteria, act as temporal and s...
متن کاملAtomic model of a cell-wall cross-linking enzyme in complex with an intact bacterial peptidoglycan.
The maintenance of bacterial cell shape and integrity is largely attributed to peptidoglycan, a highly cross-linked biopolymer. The transpeptidases that perform this cross-linking are important targets for antibiotics. Despite this biomedical importance, to date no structure of a protein in complex with an intact bacterial peptidoglycan has been resolved, primarily due to the large size and fle...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2014
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.02329-13